Histone H3K27 Modifications and Gene Transcription
نویسندگان
چکیده
منابع مشابه
Active transcription without histone modifications.
Gene expression is regulated by proteins such as transcription factors, as well as by chromatin modifications on DNA and histones. Some histone modifications have been associated to transcriptional activation (i.e. H3K4me1, H3K4me3, H3K9ac, H3K27ac or H3K36me3) whereas others with gene silencing (H3K9me3 and H3K27me3). However, and challenging this premise, we have identified a set of genes in ...
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Transcription in eukaryotes is associated with two major changes in chromatin organization. Firstly, nucleosomal histones are continuously replaced by new histones, an event that in yeast occurs predominantly at transcriptionally active promoters. Secondly, histones become modified post-translationally at specific lysine residues. Some modifications, including histone H3 trimethylation at lysin...
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ژورنال
عنوان ژورنال: Journal of Life Science
سال: 2011
ISSN: 1225-9918
DOI: 10.5352/jls.2011.21.4.616